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NVP-TAE 684
CAS No. 761439-42-3
NVP-TAE 684 ( TAE-684;TAE684; NVP TAE684 )
产品货号. M15891 CAS No. 761439-42-3
A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥413 | 有现货 |
|
| 5MG | ￥656 | 有现货 |
|
| 10MG | ￥1021 | 有现货 |
|
| 25MG | ￥1839 | 有现货 |
|
| 50MG | ￥2770 | 有现货 |
|
| 100MG | ￥3937 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NVP-TAE 684
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
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产品描述A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays; exhibits no significant cross-reactivity against other kinases; blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest; suppresses lymphomagenesis in in vivo models.Blood Cancer Discontinued
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同义词TAE-684;TAE684; NVP TAE684
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通路Angiogenesis
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靶点ALK
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受体ALK
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number761439-42-3
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分子量614.20
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分子式C30H40ClN7O3S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C(OC)=C3)CC2)CC1
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化学全称2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Galkin AV, et al. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.
2. Koivunen JP, et al. Koivunen JP, 3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.
4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.
2. Koivunen JP, et al. Koivunen JP, 3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.
4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.
产品手册
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