021-51111890
购物车（）
sales@molnova.cn
NVP-TAE 684
CAS No. 761439-42-3
NVP-TAE 684 ( TAE-684;TAE684; NVP TAE684 )
产品货号. M15891 CAS No. 761439-42-3
A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥413 | 有现货 |
|
| 5MG | ￥656 | 有现货 |
|
| 10MG | ￥1021 | 有现货 |
|
| 25MG | ￥1839 | 有现货 |
|
| 50MG | ￥2770 | 有现货 |
|
| 100MG | ￥3937 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称NVP-TAE 684
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
-
产品描述A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays; exhibits no significant cross-reactivity against other kinases; blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest; suppresses lymphomagenesis in in vivo models.Blood Cancer Discontinued
-
同义词TAE-684;TAE684; NVP TAE684
-
通路Angiogenesis
-
靶点ALK
-
受体ALK
-
研究领域Cancer
-
适应症Blood cancer
化学信息
-
CAS Number761439-42-3
-
分子量614.20
-
分子式C30H40ClN7O3S
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESCN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C(OC)=C3)CC2)CC1
-
化学全称2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Galkin AV, et al. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.
2. Koivunen JP, et al. Koivunen JP, 3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.
4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.
2. Koivunen JP, et al. Koivunen JP, 3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.
4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.
产品手册
关联产品
-
Tyrphostin AG 879
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
-
CEP-28122
A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
-
LDK378 dihydrochlori...
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7, and 23 nM, respectively).
